| 1. Title: Estrogen therapy: the dangerous road to Shangri-La. Source: CONSUMER REPORTS. 1976 Nov;41(11):642-5. Abstract: The use of estrogens almost tripled during the 1965-75 period, with usage concentrated as a cure-all for aging, for the degenerative diseases associated with aging, and for the emotional difficulties of middle age. 3 separate studies published in the last year have shown a high level of association between estrogen use and the development of endometrial cancer. Results of these studies coupled with the significant recent increase in the incidence of cancer in women over 50 who are in the high socioeconomic groups--the groups most likely to use estrogen therapy--emphasize the association. The U.S. FDA has proposed a modification in the labeling for estrogens, and a package insert for patients which would warn of possible hazards of estrogen therapy. It is recommended that estrogen be used only for vasomotor symptoms and vaginal atrophy. The lowest possible effective dosage should be used and for the shortest possible amount of time. Earlier studies had suggested that estrogen replacement therapy might protect against breast cancer; most recent studies suggest the opposite. In addition, estrogen may trigger high blood pressure and increase some blood clotting. Women with high blood pressure or a family history of early heart attacks are contraindicated from using estrogen therapy. Even for the treatment of osteoporosis, there may be safer alternative therapies. Women are cautioned as to their own responsibilities when taking estrogens. Language: English Keywords: ESTROGENS | MENOPAUSE | CANCER | ADMINISTRATION AND DOSAGE | SIDE EFFECTS | ENDOMETRIAL CANCER | PROMOTION | CARDIOVASCULAR EFFECTS | BREAST CANCER | CENTRAL NERVOUS SYSTEM EFFECTS | DEPRESSION | Hormones | Endocrine System | Physiology | Biology | Reproduction | Neoplasms | Diseases | Drugs | Treatment | Marketing | Economic Factors | Central Nervous System | Mental Disorders Document Number: 766912 |
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