| 1. Title: Africa: problems getting antiretrovirals for trials. Source: AIDS Treatment News. 2003 May 30;(391):5-6. Abstract: Researchers are having continuing difficulties getting the drugs for trials of antiretrovirals in developing countries. Writer Jon Cohen outlined the problem in an article in the current Science magazine. The U.S. National Institutes of Health conducts some drug trials in developing countries -- but will not pay for the drugs, which are normally donated by the manufacturer for U.S. trials leading to drug approval. But generally the drugs used in these developing-country trials have already been approved in the U.S., and companies have little incentive to donate them for these trials, which usually focus on operations research on how to best deliver treatment in developing countries. And for ethical reasons the U.S. insists that patients be offered continued treatment after the trial -- a disincentive for the manufacturers or anyone else to provide drugs. For various reasons the researchers often cannot or do not want to use lower-cost generic versions of the drugs. (excerpt) Language: English Keywords: AFRICA | CLINICAL TRIALS | CLINICAL RESEARCH | TREATMENT | ANTIRETROVIRAL DRUGS | ETHICS | NONGOVERNMENTAL ORGANIZATIONS | Developing Countries | Research Methodology | Organizations Document Number: 190388 |
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