| 1. Title: Evaluating fetomaternal hemorrhage by alphafetoprotein and Kleihauer following therapeutic abortions. Author: Hay DL; Horacek I; Paull J Source: International Journal of Gynaecology and Obstetrics. 1982 Feb;20(1):1-3. Abstract: In a survey of 75 patients at 6-11 weeks gestation, fetomaternal hemorrhage (FMH) was detected by significant rises (>2S.D.) in maternal alphafetoprotein (AFP) levels in 57% of patients, while increased fetal cells were detected by Kleihauer test in 24% of patients. With increasing gestation, FMH was detected more readily by both tests; however, in evaluating FMH at less than 10 weeks gestation, AFP was found to be a more sensitive and reliable marker than the Kleihauer test. We suggest that there is a gray zone for the Kleihauer test in early gestation, when erythroblasts containing embryonic hemoglobins are gradually replaced in the fetal circulation by erythrocytes containing fetal hemoglobin. (author's) Language: English Keywords: ABORTION | PREGNANCY, FIRST TRIMESTER | ALPHA FETOPROTEINS | BLEEDING | LABORATORY PROCEDURES | HEMOGLOBIN LEVEL | ANALYSIS | AGE FACTORS | Fertility Control, Postconception | Family Planning | Pregnancy | Reproduction | Blood Proteins | Hemic System | Physiology | Biology | Signs and Symptoms | Diseases | Laboratory Examinations and Diagnoses | Examinations and Diagnoses | Research Methodology | Population Characteristics | Demographic Factors | Population Document Number: 009851 Notification |
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